Tom Izzo laughs at those who get caught by the 5/12 upset. He's been a 5-seed twice before, going to the Final Four as one in 2005 and the Sweet 16 as one in 2008. In fact, he's never lost in the first weekend when seeded as a five or better.
However, Kansas is likely to bring the train to a halt in the regional semifinals. Bill Self is three-for-three at getting at least to the Elite Eight when he's a 1-seed (2001, 2007, 2008), and he's also three-for-three at getting at least to the Elite Eight when his regular season winning percentage is greater than .800. This season Kansas is a 1-seed and his team went 32-2 (.941).